The Derome Laboratory has an exceptional opportunity available for two PhD students to join our research team:
Project BeeProbio3: High throughput and integrative insect model to model the interplay of stress factors controlling host-microbiota interactions at the interface of health/disease.
Project ZEBRIGHTmicro: Optimizing an instant, high throughput and integrative vertebrate model to decipher the interplay of factors controlling host-microbiota interactions along development at the interface of health/disease.
Candidates must apply before Aug 30th, 2019 (send CV, cover letter and two letters of support to firstname.lastname@example.org). More information in the "Work with us" section or the links above.
It overviews state-of-the-art knowledge on free-living and host-associated microbiota and their importance on both fish health and the long-term sustainability of fish farming. It also addresses high throughput techniques to monitor those host-microbiota interactions. Applications that resulted from microbiota monitoring studies (e.g. improve water quality, prevent opportunistic infections and improving fish performance) are also discussed.
Goal: Developing an instant, high throughput and integrative insect larvae model to decipher the interplay of factors controlling host-microbiota interactions for biotransforming waste biomass into high value biochemicals. Skills: Background in molecular biology and bioinformatics, excellent communication and teamwork skills. Salary: CAD $21,000 per year, for 3 years.
To access the article, click here. (for personal use only, do not redistribute this link)
Here we present an integrative timeline of key events in bioinformatics and related fields during the past half-century, as well as some background on parallel advances in molecular biology and computer science, and some reflections on the future of bioinformatics.
Congratulations to Amine Chaabane, who was awarded a Sentinel North scholarship for international graduate students.
Through this program, Sentinel North seeks to attract new talent, foster the development of young international scientists able to tackle and help resolve complex northern issues, and encourage the sharing of knowledge and experience across borders.
Amine's project aims to study two populations of Arctic char (Salvelinus alpinus) from the North region of Canada and trying to observe the impact of climate change and physiological parameters differences on this microbiota. For more information about the Sentinel North international scholarship program, click here.
Frontiers in Ecology and Evolution | doi: 10.3389/fevo.2018.00058 (Full-text will be available on Frontiers soon)
ABSTRACT: Honey bees (Apis mellifera) are facing multiple stressors affecting their lifespan, health and productivity. Among them, Nosema ceranae is an intracellular microsporidian parasite, which plays a major impact on honey bees colonies. However, both efficiency and innocuity of current treatment against N. ceranae are observed, thus raising the urgent need to develop alternative prophylactic and curative strategies. Endogenous microbial...
Abstract: Adaptation of microbial communities to anthropogenic stressors can lead to reductions in microbial diversity and disequilibrium of ecosystem services. Such adaptation can change the molecular signatures of communities with differences in taxonomic and functional composition. Understanding the relationship between taxonomic and functional variation remains a critical issue in microbial ecology. Here, we assessed the taxonomic and functional diversity of a lake metacommunity system along a polymetallic pollution gradient caused by 60 years of chronic exposure to acid mine drainage (AMD). Our results highlight three adaptive signatures. First, a signature of taxon—function decoupling was detected in the microbial communities of moderately and highly polluted lakes. Second, parallel shifts in taxonomic composition occurred between polluted and unpolluted lakes. Third, variation in the abundance of functional modules suggested a gradual deterioration of ecosystem services (i.e., photosynthesis) and secondary metabolism in highly polluted lakes. Overall, changes in the abundance of taxa, function, and more importantly the polymetallic resistance genes such as copA, copB, czcA, cadR, cCusA, were correlated with trace metal content (mainly Cadmium) and acidity. Our findings highlight the impact of polymetallic pollution gradient at the lowest trophic levels.
Aeromonas sobria is a mesophilic motile aeromonad for which, despite increasing evidence of mutualistic interactions in salmonid fish, the determinants of its host-microbe associations remain poorly understood. The ongoing confusion between A. sobria (sensu stricto) and A. veronii bv. sobria further increases this knowledge gap.
In this new publication, we assessed the genomic and phenotypic heterogeneity among five A. sobria strains. Two clinical isolates recovered from infected fish (JF2635 and CECT 4245), one from an infected amphibian (08005) and two recently isolated brook charr probionts (TM12 and TM18) which inhibit in vitro growth of A. salmonicida subsp. salmonicida (a salmonid fish pathogen).
In this publication, we report two novel Pseudomonas fluorescens strains isolated from the walleye gut microbiota. Those two strains improved by 54% the survival of walleye juveniles infected by Flavobacterium columnare, a major opportunistic pathogen of walleye and salmonid fish.
(To view this article, click on the title above.)
Vertically and horizontally transmitted microbial symbionts shape the gut microbiota ontogenesis of a skin-mucus feeding discus fish progeny Scientific Reports 7:5263 (2017)
This new publication, authored by François-Étienne Sylvain and Nicolas Derome, discusses the gut microbiota acquisition patterns in the Discus fish, which display a unique parenting behaviour by feeding their fry off their own skin mucus in the early life stages.