Martin Llewellyn, Ph.D. 
  • Position: Research Fellow
  • Email: martllewellyn@gmail.com
  • Skype: martin_llewellyn
  • Location: School of Biological Sciences, Bangor University, Deiniol Road, Bangor, Gwynedd, LL57 2UW, U

CV

EDUCATION
  • 2009 PhD, London School of Hygiene and Tropical Medicine – “The molecular epidemiology of Trypanosoma cruzi infection in wild and domestic transmission cycles, with special emphasis on multilocus microsatellite analysis”.
  • 2002 BA (Hons), Oxford University, Biological Sciences

CAREER
  • 2012–2015 – Marie Curie Research Fellow, Department of Biology, Universite de Laval, Quebec & School of Biological Sciences, Bangor University, UK.
  • 2009–2012 – ChagasEpiNet – Post-doctoral researcher – London School of Hygiene and Tropical Medicine.
  • 2010 – Visiting Research Fellow – Facultad de Medicina, Universidad Mayor de San Simon, Cochabamba, Bolivia.
  • 2007 – Visiting Research Fellow – Instituto de Medicina Tropical, Universidad Central De Venezuela, Caracas.
  • 2005 & 2007 – Visiting Research Fellow – Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia
  • 2004 – Visiting Research Fellow – Instituto Evandro Chagas, Belem, Para, Brazil.

GRANTS AND AWARDS
  • 2012–2015 – FishProBio Marie Curie Fellowship – Salmonid microbiomes in health and disease, Principal Investigator – €248,220
  • 2011–2013 – DeepCruzi transnational access project, ESGI consortium – Intra-host genetic diversity in T. cruzi, Principal Investigator – €85,000
  • 2009–2012 – ChagasEpiNet EC Fp7 Consortium – Molecular Epidemiology of Chagas disease, named researcher – €2,876,507
  • 2009 – De Lazslo Foundation – Chagas disease origins in man – £4,000
  • 2007 – Gordon Smith Scholarship – Emergent Chagas Disease in Northern Bolivia – £5,000
  • 2005 – Swire Trust Travelling Scholoarship – The molecular epidemiology of human trypansomiasis in Venezuela – £5,000

Publications

  1. Llewellyn, MS. Messenger, LM. Derome, N. Delepine, M. Deluze, JF. Miles, MA 2014 Deep sequencing of the Trypanosoma cruzi GP63 surface proeteases reveals crytpic diversity in chronic and congenital Chagas Disease patients. In preparation.
  2. Baleela, R Llewellyn MS Fitzpatrick, S Kuhls, K Schönian, G Miles MA Mauricio IL 2014 Leishmania donovani populations in Eastern Sudan: temporal structuring and a link between human and canine transmission. In preparation
  3. Lima, V. Jansen, AM, Messenger, LM. Miles, MA. Llewellyn, MS. 2014 Wild Trypanosoma cruzi I genetic diversity in Brazil suggests admixture and disturbance in parasite populations from the Atlantic Forest region. PLoS Negl Trop Dis. Accepted.
  4. Llewellyn MS, Boutin, SA. Hossein, S, Derome, N 2014 Teleost microbiomes: progress towards characterisation, manipulation and applications in aquaculture and fisheries. Frontiers in Microbiology. Accepted
  5. Segovia M, Carrasco HJ, Martínez CE, Messenger LA, Nessi A, Londoño JC, Espinosa R, Martínez C, Alfredo M, Bonfante-Cabarcas R, Lewis MD, de Noya BA, Miles MA, Llewellyn MS. 2013 Molecular epidemiologic source tracking of orally transmitted Chagas disease, Venezuela. Emerg Infect Dis. 19:1098-101
  6. Tomasini N, Lauthier JJ, Llewellyn MS, Diosque P. 2013 MLSTest: novel software for multi-locus sequence data analysis in eukaryotic organisms. Infect Genet Evol. 20:188-96.
  7. Zumaya-Estrada FA, Messenger LA, Lopez-Ordonez T, Lewis, MD , Flores-Lopez CA, Martínez-Ibarra JA, Pennington PM, Cordon-Rosales C, Carrasco HJ, Segovia M, Miles MA, Llewellyn MS 2012 North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype. Parasites and Vectors. 5:226 doi:10.1186/1756-3305-5-226
  8. Franzén, O. Talavera-López, C. Ochaya, S. Butler, CE. Messenger, LA. Lewis, MD. Llewellyn, MS. Marinkelle, CJ Tyler, KM Miles MA, Andersson BA (2012) Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei. BMC Genomics. 13:531
  9. Ramírez, JD, Guhl, F, Messenger, LA, Lewis, MD, Montilla, M, Cucunuba, Z, Miles, MA; Llewellyn, MS. (2012) Contemporary cryptic sexuality in Trypanosoma cruzi. Molecular Ecology. 21: 4216–4226,
  10. Carrasco HJ, Segovia M, Llewellyn MS, Morocoima A, Urdaneta-Morales S, et al. (2012) Geographical Distribution of Trypanosoma cruzi Genotypes in Venezuela. PLoS Negl Trop Dis 6(6): e1707.
  11. Lauthier JJ, Tomasini N, Barnabé C, Rumi MM, D'Amato AM, Ragone PG, Yeo M, Lewis MD, Llewellyn MS, Basombrío MA, Miles MA, Tibayrenc M, Diosque P. (2012) Candidate targets for Multilocus Sequence Typing of Trypanosoma cruzi: validation using parasite stocks from the Chaco Region and a set of reference strains. Infect Genet Evol. 12(2):350-8
  12. Messenger LA, Llewellyn MS, Bhattacharyya T, Franzén O, Lewis MD, et al. (2012) Multiple Mitochondrial Introgression Events and Heteroplasmy in Trypanosoma cruzi Revealed by Maxicircle MLST and Next Generation Sequencing. PLoS Negl Trop Dis 6(4): e1584 doi:10.1371/journal.pntd.0001584
  13. Zingales B, Miles MA, Campbell DA, Tibayrenc M, Macedo AM, Teixeira MM, Schijman AG, Llewellyn MS, Lages-Silva E, Machado CR, Andrade SG, Sturm NR.(2012) The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications. Infect Genet Evol.12:240-53
  14. Llewellyn, M.S., Rivett-Carnac, J.B., Fitzpatrick, S., Lewis, M. D., Yeo, M., Gaunt M.W., Miles M.A., Extraordinary Trypanosoma cruzi diversity within single mammalian reservoir hosts implies a mechanism of diversifying selection. Int J Parasitol. 41(6):609-14.
  15. Franzen, O. Ochaya, S. Sherwood, E. Lewis, M. Llewellyn, M. 2011 Miles, M. Andersson, B. 2011 Shotgun Sequencing Analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener. PLoS Negl Trop Dis 5(3):e984
  16. Yoshida, N. Tyler K.M., Llewellyn, M.S. 2011 Invasion mechanisms among emerging food borne protozoan parasites. Trends in Parasitology. 27(10):459-66
  17. Yeo M, Mauricio IL, Messenger LA, Lewis MD, Llewellyn MS, Nidia Acosta1,Tapan Bhattacharyya, Patricio Diosque, Hernan J. Carrasco, Michael A. Miles (2011) Multilocus Sequence Typing (MLST) for Lineage Assignment and High Resolution Diversity Studies in Trypanosoma cruzi. PLoS Negl Trop Dis 5(6): e1049.
  18. Ocaña-Mayorga S, Llewellyn MS, Costales JA, Miles MA, Grijalva MJ, 2010 Sex, Subdivision, and Domestic Dispersal of Trypanosoma cruzi Lineage I in Southern Ecuador. PLoS Negl Trop Dis 4(12): e915.
  19. Hamilton, P.B., Lewis, M.D., Cruickshank, C., Gaunt, M.W., Yeo, M., Llewellyn, M.S., Valente, S.A., Maia da Silva, F., Stevens, J.R., Miles, M.A., Teixeira, M.M., 2010 Identification and lineage genotyping of South American trypanosomes using fluorescent fragment length barcoding. Infect Genet Evol 11, 44-51.
  20. Bhattacharyya, T., Brooks, J., Yeo, M., Carrasco, H.J., Lewis, M.D., Llewellyn, M.S., Miles, M.A., 2010 Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology. Int J Parasitol. 40(8):921-8
  21. Llewellyn, M.S., Miles, M.A., Carrasco, H.J., Lewis, M.D., Yeo, M., Vargas, J., Torrico, F., Diosque, P., Valente, V., Valente, S.A., Gaunt, M.W., 2009. Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection. PLoS Pathog 5, e1000410.
  22. Llewellyn, M.S., Lewis, M.D., Acosta, N., Yeo, M., Carrasco, H.J., Segovia, M., Vargas, J., Torrico, F., Miles, M.A., Gaunt, M.W., 2009. Trypanosoma cruzi IIc: Phylogenetic and Phylogeographic Insights from Sequence and Microsatellite Analysis and Potential Impact on Emergent Chagas Disease. PLoS Negl Trop Dis 3, e510.
  23. Lewis, M.D., Llewellyn, M.S., Gaunt, M.W., Yeo, M., Carrasco, H.J., Miles, M.A., 2009. Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids. Int J Parasitol 39, 1305-1317.
  24. Lewis, M.D., Ma, J., Yeo, M., Carrasco, H.J., Llewellyn, M.S., Miles, M.A., 2009. Genotyping of Trypanosoma cruzi: systematic selection of assays allowing rapid and accurate discrimination of all known lineages. Am J Trop Med Hyg 81, 1041-1049.
  25. Marcili, A., Lima, L., Valente, V.C., Valente, S.A., Batista, J.S., Junqueira, A.C., Souza, A.I., da Rosa, J.A., Campaner, M., Lewis, M.D., Llewellyn, M.S., Miles, M.A., Teixeira, M.M., 2009. Comparative phylogeography of Trypanosoma cruzi TcIIc: New hosts, association with terrestrial ecotopes, and spatial clustering. Infect Genet Evol. 9(6):1265-74
  26. Miles, M.A., Llewellyn, M.S., Lewis, M.D., Yeo, M., Baleela, R., Fitzpatrick, S., Gaunt, M.W., Mauricio, I.L., 2009. The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future. Parasitology 136, 1509-1528.
  27. Yeo, M., Acosta, N., Llewellyn, M., Sanchez, H., Adamson, S., Miles, G.A., Lopez, E., Gonzalez, N., Patterson, J.S., Gaunt, M.W., Arias, A.R., Miles, M.A., 2005. Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids. Int J Parasitol 35, 225-233.
  28. Yeo, M., Lewis, M.D., Carrasco, H.J., Acosta, N., Llewellyn, M., da Silva Valente, S.A., de Costa Valente, V., de Arias, A.R., Miles, M.A., 2006. Resolution of multiclonal infections of Trypanosoma cruzi from naturally infected triatomine bugs and from experimentally infected mice by direct plating on a sensitive solid medium. Int J Parasitol 37, 111-120.
  29. Kassen, R., Llewellyn, M., Rainey, P.B., 2004. Ecological constraints on diversification in a model adaptive radiation. Nature 431, 984-988.